Molecular Biology and Genetics Core Laboratory – Objectives

The overall objective of this Core is to provide support of diabetes-related research projects by supplying cutting-edge technology and know-how in molecular biology and genetics. The specific objectives are:

  • Advice and training in the design and conduct of genetic studies of diabetes and its complications
    • Advice on study design – genome-wide association studies, whole-exome and whole-genome sequencing
    • Power calculations
    • Sample collection strategies
    • Genotyping and sequencing strategies
    • Data analysis including data management and quality control
  • Develop public databases of diabetes genes and associated mutations and variants
  • Mutation analysis of monogenic diabetes genes (sample collection, DNA sequencing and analysis)
  • Genotyping of diabetes-associated variants
  • Advice, training and service in BAC recombineering for molecular biological studies