Dr. Cooks research program is focused on utilizing family and genetics studies to develop a better understanding of childhood psychiatric disorders including autism and attention deficit hyperactivity disorder, as well as related disorders such as obsessive-compulsive disorder. Dr. Cook leads the University of Chicago core facility in high throughput sequencing and genotyping, and works with leaders of local cores including Dr. Bell in testing and developing new technologies for sequencing and genotyping. His research program includes a focus on understanding the molecular and physiological function of genetic variation in affecting susceptibility to complex phenotypes. Finally, he has also been collaborating with Dr. Carole Ober in mapping and identifying genetic variation affecting serotonin levels.